The Mito Foundation PhD Scholarship

Scholar

Benjamin Padman

University

Monash University

Supervisors

Dr Georg Ramm and Dr Mark Prescott

Project Name

The spatiotemporal characterisation of signalling pathways in mammalian mitophagy

Project Synopsis

Ben’s project aims to characterise the physiological relationship between form and function in mitophagy. Mitophagy is a quality control process, where new mitochondria are created and old or dysfunctional mitochondria are degraded. If these dysfunctional mitochondria are not degraded, they can lead to a build-up which can lead to damaged components and DNA. These damaged components can then spread to other networks of the body, resulting in disorders such as mitochondrial disease. Ben’s work will look at the relationship between mitochondria and mitophagy. Using several techniques that will stimulate dysfunction in single mitochondria cells, he hopes to discover the spatiotemporal organisation of mitochondria during mitophagy.

Project updates:  February 2015 and September 2015

Ben’s research was featured in AddGene’s September 2015 newsletter. Read the article here.

To read Ben’s final report for his project, click here.