Sonlicromanol
(KH176)
Sonlicromanol is an investigational medicine. This means it is still being tested in clinical trials. It is not approved for use anywhere.
Study details
KHENERFIN (NCT06451757).
Manufacturer
Khondrion B.V.
Types of mito
Primary mitochondrial disease linked to the m.3243A>G mitochondrial DNA variant.
Which people with mito might this therapy help?
Adults with primary mitochondrial disease linked to the m.3243A>G mitochondrial DNA variant. This can include people with:
- MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes)
- MIDD (maternally inherited diabetes and deafness)
- CPEO (chronic progressive external ophthalmoplegia)
- Mitochondrial myopathy
- Multi-system mitochondrial disease.
Sonlicromanol is designed to reduce the effects of mitochondrial stress. Researchers are studying whether it can help with fatigue, muscle weakness and other symptoms in people with m.3243A>G primary mitochondrial disease.
What research has been done on this therapy?
Sonlicromanol has been studied in earlier trials, including studies in adults with m.3243A>G primary mitochondrial disease and a study in children with primary mitochondrial disease.
Khondrion say it has been studied in a Phase 1 study, and the KHENERGY, KHENERGYZE, KHENEREXT and KHENERGYC studies.
A Phase 3 study, called KHENERFIN, is now testing whether sonlicromanol can reduce fatigue and improve physical ability in adults with m.3243A>G primary mitochondrial disease.
Clinical trial information
Study name
KHENERFIN (NCT06451757).
Location
Multiple sites overseas, including Europe, UK and USA. There are no Australian sites.
Who is funding the study?
Khondrion B.V.
This study is testing whether sonlicromanol can reduce fatigue and the impact of fatigue on daily life.
It is also looking at whether sonlicromanol can improve physical ability, including balance and lower limb muscle strength.
Important information
Find out more
Emerging therapies for mito
Learn about developing therapies and opportunities to take part in research.
Clinical trials explained
A guide to help understand participation and make informed decisions.
